Journal: iScience
Article Title: Spatial transcriptomics reveals the molecular signatures of prodromal and advanced α-synucleinopathy
doi: 10.1016/j.isci.2026.114845
Figure Lengend Snippet: Overview of ST annotations and differentially expressed pathways in relation to the stage of aSyn pathology in brains of M83 +/+ mice (A) Bubble plot depicting the regionally enriched markers used for delineating 8 ST annotations in sagittal brain sections from M83 +/+ mice. (B and C) Representative low-magnification (4×) panoramic images of a sagittal brain section showing gray matter regions (in B, hematoxylin counterstain) and corresponding spatial map (in C). (D) UMAP plot depicting distinct clustering of ST profiles in annotations, which additionally includes white matter and choroid plexus based on the abundance of regional markers (in 2A; also see ). (E) UMAP plot depicting distinct clustering of ST profiles in relation to the stage of aSyn pathology in brains of M83 +/+ mice. (F) Dot plots depicting gene ontology (GO) of differentially expressed ST profiles in brains of M83 +/+ mice. The plots were generated in the STRING protein interactions database. Also see B, depicting heatmaps for all HALLMARK gene sets by disease stage and in individual regions.
Article Snippet: Hematoxylin , Vector Labs , Cat#H-3401.
Techniques: Generated